Mesotherapy is a treatment method based on the principle of injecting medicine selected according to patient’s need with appropriate dosages. Mesotherapy used for regional weight loss and cellulite treatment; is application of a thin needle in mesoderm layer by mixing lipolytic (fat busting) medicines, procirculatory medicines, tonus strengthening and cellulite eliminator medicines. Sessions are applied every 2 weeks. With the same technique applying medical ozone to cellulite layer also provides breaking in fat and cellulite. After applying Mesotherapy or regional ozone for one week, applying regional weight loss and tightening devices in 2nd week, provides the results to be more better and makes the body tighten by shaping. In order to support the treatment, drinking plentiful water is recommended.